Journal
EUROPEAN NEUROPSYCHOPHARMACOLOGY
Volume 15, Issue 2, Pages 199-201Publisher
ELSEVIER
DOI: 10.1016/j.euroneuro.2004.08.009
Keywords
vesicular monoamine transporter; stress; depression; nucleus accumbens; striatum; dopamine
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We assessed the impact of chronic swim stress in rats (daily for 3 weeks) on vesicular monoarnine transporter 2 (VMAT2) in the nucleus accumbens and striatum. Exposure to repeated swim stress resulted in significant reduction in VMAT2 density in nucleus accumbens (20%, p<0.01) and striatum subregions (21-38%, p<0.001). The down-regulation of VMAT2 in this dopaminergic regions may serve as an adaptatory mechanism in the response to prolonged stress, and may be relevant to chronic stress-induced depression. (C) 2004 Elsevier B.V. and ECNP. All fights reserved.
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