Journal
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 96, Issue 1, Pages 61-67Publisher
SPRINGER
DOI: 10.1007/s00253-012-4285-8
Keywords
Anaerobes; Antibiotics; Closthioamide; Genome mining; Clostridium; Secondary metabolites
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Funding
- Pakt fur Forschung und Innovation of the Free State of Thuringia
- Federal Ministry of Science and Technology (BMBF, Germany)
- International Leibniz Research School for Biomolecular and Microbial Interactions (ILRS), as part of the excellence graduate school Jena School for Microbial Communication (JSMC)
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Anaerobic bacteria are the oldest terrestrial creatures. They occur ubiquitously in soil and in the intestine of higher organisms and play a major role in human health, ecology, and industry. However, until lately no antibiotic or any other secondary metabolite has been known from anaerobes. Mining the genome sequences of Clostridium spp. has revealed a high prevalence of putative biosynthesis genes (PKS and NRPS), and only recently the first antibiotic from the anaerobic world, closthioamide, has been isolated from the cellulose degrading bacterium Clostridium cellulolyticum. The successful genetic induction of antibiotic biosynthesis in an anaerobe encourages further investigations of obligate anaerobes to tap their hidden biosynthetic potential.
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