Journal
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 93, Issue 6, Pages 2279-2290Publisher
SPRINGER
DOI: 10.1007/s00253-012-3928-0
Keywords
Pseudomonas putida; Cell factory; Bio-catalysis; Biofilm; Systemsmetabolic engineering; Synthetic biology; Bioeconomy
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Funding
- German Federal Ministry of Education (BMBF)
- EU
- German Federal Ministry of Education (BMBF) initiative [FKZ 0315833D]
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Since their discovery many decades ago, Pseudomonas putida and related subspecies have been intensively studied with regard to their potential application in industrial biotechnology. Today, these Gram-negative soil bacteria, traditionally known as well similar to performing xenobiotic degraders, are becoming efficient cell factories for various products of industrial relevance including a full range of unnatural chemicals. This development is strongly driven by systems biotechnology, integrating systems metabolic engineering approaches with novel concepts from bioprocess engineering, including novel reactor designs and renewable feedstocks.
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