Journal
NEUROSCIENCE LETTERS
Volume 375, Issue 3, Pages 174-177Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2004.11.017
Keywords
P50; alcoholism; event-related potential; LORETA
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P50 event-related potential was studied in abstinent chronic alcoholics to determine whether they had normal sensory gating. Repeated tones were presented to 17 recently detoxified chronic alcoholic patients and 17 healthy subjects while EEG was recorded. Low-resolution tomography (LORETA) was performed to obtain cerebral sources of P50. Abstinent chronic alcoholics showed reduced P50 sensory gating. Present results suggest an inhibitory deficit in early pre-attentive auditory sensory processing in chronic alcoholism. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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