Journal
ORGANIC LETTERS
Volume 7, Issue 5, Pages 847-849Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol047406r
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Tricyclic erythromycin A derivatives are known potent antibacterial agents, but the potential of substituted tricyclic erythromycin A derivatives remains largely unexplored. To study this lead, the tricyclic ring system was synthesized by an efficient three-step synthesis starting from the allylic alcohol utilizing a novel azidoisocyanate. These tricyclic analogues can be used as scaffolds to probe secondary ribosomal binding sites.
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