Journal
NEURON
Volume 45, Issue 5, Pages 661-666Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2005.01.025
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Funding
- NIDCD NIH HHS [R01 DC04729, R01 DC02174] Funding Source: Medline
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One of the most fundamental tenets in the field of olfaction is that each olfactory receptor neuron (ORN) expresses a single odorant receptor. However, the one receptor-one neuron principle is difficult to establish rigorously. Here we construct a receptor-to-neuron map for an entire olfactory organ in Drosophila and find that two receptor genes are coexpressed in one class of ORN. Both receptors are functional in an in vivo expression system, they are only 16% identical in amino acid sequence, and the genes that encode them are unlinked. Most importantly, their coexpression has been conserved for >45 million years. Expression of multiple odor receptors in a cell provides an additional degree of freedom for odor coding.
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