4.8 Article

Extending pummerer reaction chemistry.: Synthesis of (±)-dibromophakellstatin by oxidative cyclization of an imidazole derivative

Journal

ORGANIC LETTERS
Volume 7, Issue 5, Pages 929-931

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol0500113

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The diastereoselective oxidative cyclization of a dihydrooroiclin derivative is reported. The thioimidate product formed by application of a new variant of the Pummerer reaction serves as a precursor to dibromophakellstatin.

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