Journal
ORGANIC LETTERS
Volume 7, Issue 5, Pages 867-870Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol047368b
Keywords
-
Categories
Funding
- NCI NIH HHS [CA 27489] Funding Source: Medline
Ask authors/readers for more resources
A catalytic route for enantioselective total synthesis of cell adhesion inhibitor BIRT-377 is described. The quaternary stereocenter was constructed through L-proline-derived, tetrazole-catalyzed direct asymmetric alpha-amination of 3-(4-bromophenyl)-2-methylpropanaI with dibenzyl azodicarboxylate. In the course of these studies, a one-pot trifluoro acetylation/selective benzyloxycarbonyl deprotection method was developed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available