Journal
SYNLETT
Volume -, Issue 4, Pages 619-622Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2005-863720
Keywords
sonogashira coupling; palladium; catalysis; heterogeneous
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An easy copper-, ligand and amine-free Sonogashira coupling reaction catalyzed by commercially available palladium on carbon with air at low catalyst loading (0.2 mol% Pd) has been developed. Aryl iodides coupled with aromatic alkynes gave good to excellent yields and with aliphatic alkyne gave moderate to good yields. The reaction system is easy to handle.
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