Journal
TETRAHEDRON
Volume 61, Issue 10, Pages 2659-2665Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2005.01.061
Keywords
aza Claisen; azecine; azonine; 9-membered rings; 10-membered rings; adrenaline
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This paper describes the synthesis of functionalised azecine and azonine derivatives incorporating the adrenaline motif. In a key step, an enolate assisted aza Claisen rearrangement was employed to interconvert from 6- and 5-membered heterocycles to their corresponding 10- and 9-membered lactams. (C) 2005 Elsevier Ltd. All rights reserved.
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