Journal
VACCINE
Volume 23, Issue 15, Pages 1770-1778Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2004.11.003
Keywords
plant-made pharmaceutical; post-translational modification; recombinant therapeutic protein
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Plants have become, over the last ten years, a suitable alternative to microbial and animal cell factories for the production of clinically-useful, therapeutic proteins. Besides the well known advantage of low-cost and large-scale production of safe and biologically active mammalian proteins, plants also are able to perform most post-translational maturations required for biological activity and suitable pharmacokinetics of recombinant therapeutic proteins. In this short review we focus on glycosylation and proteolytic processing of plant-made pharmaceuticals during their transport through the plant cell's secretory pathway. We also address the practical implications of these important processes on the effectiveness of plant molecular pharming systems. (c) 2004 Published by Elsevier Ltd.
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