Journal
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 90, Issue 4, Pages 1333-1345Publisher
SPRINGER
DOI: 10.1007/s00253-011-3149-y
Keywords
phi KMV-like bacteriophage; Genome; Klebsiella pneumoniae; Phage therapy; Podoviridae; phiKMV-like viruses
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Funding
- Polish Ministry of Science and Higher Education [N N401 3550 33]
- Natural Sciences and Engineering Research Council of Canada
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Bacteriophage KP34 is a novel virus belonging to the subfamily Autographivirinae lytic for extended-spectrum beta-lactamase-producing Klebsiella pneumoniae strains. Its biological features, morphology, susceptibility to chemical and physical agents, burst size, host specificity and activity spectrum were determined. As a potential antibacterial agent used in therapy, KP34 molecular features including genome sequence and protein composition were examined. Phylogenetic analyses and clustering of KP34 phage genome sequences revealed its clear relationships with phiKMV-like viruses. Simultaneously, whole-genome analyses permitted clustering and classification of all phages, with completely sequenced genomes, belonging to the Podoviridae.
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