Journal
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 90, Issue 6, Pages 1817-1827Publisher
SPRINGER
DOI: 10.1007/s00253-011-3285-4
Keywords
Oxygenases/hydroxylases; Peroxidases; Laccases; Bacteria; Aromatic compounds; Hydroxylation reaction
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Funding
- USAITC-A [W911NF-10-1-0204]
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Redox enzymes are ubiquitous in all living organisms. In fact, oxidation and reduction reactions are fundamental for the transformation of cellular and external compounds both for cell reproduction and for energy production. Redox enzymes share a common characteristic that is the capacity of transferring electrons to and from molecules. In addition, microorganisms contain many oxidative enzymes, and because they are relatively easier to cultivate and study, they have been investigated in details, in particular for potential use in biotechnological field. One important reaction that oxidative enzymes perform is the introduction of one or two oxygen atoms on aromatic compounds. The most representative classes of enzymes that perform this reaction are oxygenases/hydroxylases, peroxidases, and laccases; they differ in many aspects: the metal present in the active site, the used reductive cofactor, the final oxidant, and the number of electrons transferred in each step. Their essential features and mechanisms of action have been the subject of several studies, together with some structural analyses. This review reports recent developments and summarizes some of the most interesting results concerning both structural requirements and mechanisms implicated in aromatic hydroxylation.
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