Journal
SCIENCE
Volume 307, Issue 5715, Pages 1634-1638Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1107580
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Funding
- NIGMS NIH HHS [5T32GM007276, T32 GM007276, R01 GM066258, R01 GM066258-04, R01 GM66258-01] Funding Source: Medline
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Brassinosteroid (BR) homeostasis and signaling are crucial for normal growth and development of plants. BR signaling through cell-surface receptor kinases and intracellular components leads to dephosphorylation and accumulation of the nuclear protein BZR1. How BR signaling regulates gene expression, however, remains unknown. Here we show that BZR1 is a transcriptional repressor that has a previously unknown DNA binding domain and binds directly to the promoters of feed back-regulated BR biosynthetic genes. Microarray analyses identified additional potential targets of BZR1 and illustrated, together with physiological studies, that BZR1 coordinates BR homeostasis and signaling by playing dual roles in regulating BR biosynthesis and downstream growth responses.
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