Journal
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 88, Issue 1, Pages 327-339Publisher
SPRINGER
DOI: 10.1007/s00253-010-2737-6
Keywords
Bioavailability; Dose-response analysis; Micelle; Nonionic surfactant; Cloud point system
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Funding
- National Natural Science Foundation of China [20676080]
- HI-TECH Research and Development Program of China (863) [2007AA02Z225]
- Shanghai Jiao Tong University, Shanghai, China [T241460631]
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It is uncertain in some extent that organic compounds solubilized in micelles of a nonionic surfactant aqueous solution are bioavailable directly by the microbes in an extractive microbial transformation or biodegradation process. In this work, a dose-response method, where a bioequivalence concept is introduced to evaluate the synergic toxicity of the nonionic surfactants and the organic compounds, was applied to analyze the inhibition effect of organic compounds ( naphthalene, phenyl ether, 2-phenylethanol, and 1-butanol) in nonionic surfactant Triton X-100 micelle aqueous solutions and Triton X-114 in aqueous solutions forming cloud point systems. Based on the result, a mole solubilization ratio of organic compounds in micelle was also determined, which consisted very well with those of classic semi-equilibrium dialysis experiments. The results exhibit that bioavailability of organic compounds solubilized in micelles to microbial cells is negligible, which provides a guideline for application of nonionic surfactant micelle aqueous solutions or cloud point systems as novel media for microbial transformations or biodegradations.
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