Journal
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 87, Issue 2, Pages 457-466Publisher
SPRINGER
DOI: 10.1007/s00253-010-2576-5
Keywords
Ganoderic acids; Ganoderma lucidum; Medicinal mushroom fermentation; Biosynthesis; Bioactivities; Application
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Funding
- National Natural Science Foundation of China [20776084, 30821005]
- National High Technology RD Program [2007AA021506]
- Shanghai Science and Technology Commission [08DZ1971900]
- Shanghai Leading Academic Discipline Project
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Ganoderic acids (GAs), a kind of highly oxygenated lanostane-type triterpenoids, are important bioactive constituents of the famous medicinal mushroom Ganoderma lucidum. They have received wide attention in recent years due to extraordinarily pharmacological functions. Submerged fermentation of G. lucidum is viewed as a promising technology for production of GAs, and substantial efforts have been devoted to process development for enhancing GA production in the last decade. This article reviews recent publication about fermentative production of GAs and their potential applications, especially the progresses toward manipulation of fermentation conditions and bioprocessing strategies are summarized. The biosynthetic pathway of GAs is also outlined.
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