Journal
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 85, Issue 5, Pages 1339-1351Publisher
SPRINGER
DOI: 10.1007/s00253-009-2354-4
Keywords
Bioreactor; Secondary metabolism; Co-cultures; Disposable reactors
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Funding
- Arkansas Biosciences Institute
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Despite significant efforts over nearly 30 years, only a few products produced by in vitro plant cultures have been commercialized. Some new advances in culture methods and metabolic biochemistry have improved the useful potential of plant cell cultures. This review will provide references to recent relevant reviews along with a critical analysis of the latest improvements in plant cell culture, co-cultures, and disposable reactors for production of small secondary product molecules, transgenic proteins, and other products. Some case studies for specific products or production systems are used to illustrate principles.
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