Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 191, Issue 6, Pages 1010-1013Publisher
UNIV CHICAGO PRESS
DOI: 10.1086/428137
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Funding
- NIAID NIH HHS [R01 AI47953-01A1] Funding Source: Medline
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Malaria in pregnancy is a serious complication associated with parasitized erythrocyte (PE) sequestration in the placenta. Recent work suggests that var genes could play an important role in PE binding to chondroitin sulfate A (CSA), a primary placental adherence receptor. Here, we confirm that var2CSA is transcriptionally up-regulated in CSA-binding parasites and define CSA-binding domains in var2CSA. The identification of multiple binding domains in var2CSA strengthens the evidence for their involvement in malaria during pregnancy and may have applications for the development of a vaccine against malaria in pregnancy.
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