Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 13, Issue 6, Pages 2157-2165Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2004.12.051
Keywords
4-aminoquinoline; antimalarial; heam binding
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This study describes the synthesis of new 4-aminoquinoline derivatives and evaluation of their activity against a chloroquine sensitive strain of P. falciparum in vitro and chloroquine resistant N-67 strain of P. yoelii in vivo. All the analogues were found to form strong complex with hematin and inhibit the P-hematin formation in vitro. These results suggest that these compounds act on heme polymerization target. (c) 2005 Elsevier Ltd. All rights reserved.
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