Fluoro, alkylsulfanyl, and alkylsulfonyl leaving groups in Suzuki cross-coupling reactions of purine 2′-deoxynucleosides and nucleosides

[GRAPHICS] Protected 2'-deoxynucleoside and nucleoside derivatives of 6-fluoropurine, 6-(3-methylbutyl)sulfanylpurine, and 6-(3-methylbutyl)ylsulfonyipurine undergo nickel- or palladium-mediated C-C cross-coupling with arylboronic acids to give good yields of 6-arylpurine products.