Journal
SCIENCE
Volume 307, Issue 5716, Pages 1781-1785Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1106823
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Funding
- NIGMS NIH HHS [R01 GM035527, R37 GM035527, GM35527] Funding Source: Medline
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Coordination of cytokinesis with chromosome congression and segregation is critical for proper cell division, but the mechanism is unknown. Here, septins, a conserved family of polymerizing guanosine triphosphate-binding proteins, localized to the metaphase plate during mitosis. Septin depletion resulted in chromosome loss from the metaphase plate, lack of chromosome segregation and spindle elongation, and incomplete cytokinesis upon delayed mitotic exit. These defects correlated with loss of the mitotic motor and the checkpoint regulator centromere-associated protein E (CENP-E) from the kinetochores of congressing chromosomes. Mammalian septins may thus form a mitotic scaffold for CENP-E and other effectors to coordinate cytokinesis with chromosome congression and segregation.
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