Journal
INTERNATIONAL JOURNAL OF CARDIOLOGY
Volume 99, Issue 2, Pages 337-339Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2003.11.038
Keywords
hypoxia inducible factor-1 expression; ischemia; acute myocardial infarction
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We report hypoxia-inducible factor-1 (HIF-1) expression in myocardium of patients with recent acute myocardial infarction (AMI), supporting the hypothesis of HIF-1 as a possible mediator of response to ischemia. A potential diagnostic role of determining tissue expression of HIF-1 as a marker of ischemia, and potential therapeutic implications by trying to modulate HIF-1 activity in order to promote beneficial effects of HIF-1 related genes (e.g. expression of vascular endothelial growth factor (VEGF)) may derive. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
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