Journal
SCIENCE
Volume 307, Issue 5716, Pages 1776-1778Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1104882
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Funding
- NIGMS NIH HHS [GM49164] Funding Source: Medline
- NINDS NIH HHS [NS043231, NS33347] Funding Source: Medline
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Recognizing a deficiency of indispensable amino acids (IAAs) for protein synthesis is vital for dietary selection in metazoans, including humans. Celts in the brain's anterior piriform cortex (APC) are sensitive to IAA deficiency, Signaling diet rejection and foraging for complementary IAA sources, but the mechanism is unknown. Here we report that the mechanism for recognizing IAA-deficient foods follows the conserved general control (GC) system, wherein uncharged transfer RNA induces phosphorylation of eukaryotic initiation factor 2 (elF2) via the GC nonderepressing 2 (GCN2) kinase. Thus, a basic mechanism of nutritional stress management functions in mammalian brain to guide food selection for survival.
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