Journal
SCIENCE
Volume 307, Issue 5716, Pages 1778-1781Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1106469
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Funding
- NIAID NIH HHS [AI44193, R01 AI044193, R01 AI044193-07, AI53694, R01 AI053694-03, R01 AI053694] Funding Source: Medline
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The mammalian intestine harbors a beneficial microbiota numbering approximately 10(12) organisms per gram of colonic content. The host tolerates this tremendous bacterial. load while maintaining the ability to efficiently respond to pathogenic organisms. In this study, we show that the Bacteroides use a mammalian-like pathway to decorate numerous surface capsular polysaccharides and glycoproteins with L-fucose, an abundant surface molecule of intestinal epithelial cells, resulting in the coordinated expression of this surface molecule by host and symbiont. A Bacteroides mutant deficient in the ability to cover its surface with L-fucose is defective in colonizing the mammalian intestine under competitive conditions.
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