Journal
SYNLETT
Volume -, Issue 5, Pages 845-847Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2005-863730
Keywords
palladium; catalysis; amino acids; deuteration; regio-selectivity
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A facile and efficient deuteration method of phenylalanine derivatives using a Pd/C-H-2-D2O system has been developed. Selective deuteration at the beta-position of phenylalanine derivatives occurred using Pd/C as a catalyst with high deuterium efficiency without racemization at 110 degrees C. Also, the alpha-position was deuterated at higher temperature.
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