Journal
MOLECULAR BRAIN RESEARCH
Volume 134, Issue 1, Pages 57-66Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molbrainres.2004.09.017
Keywords
Parkinson's disease; glial cells; substantia nigra; MPTP
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The biochemical and cellular changes that occur following administration of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) are remarkably similar to that seen in idiopathic Parkinson's disease (PD). In this review, we detail the molecular activities of this compound from peripheral intoxication through its various biotransformations. In addition, we detail the interplay that occurs between the different cellular compartments (neurons and glia) that eventually consort to kill substantia nigra pars compacta (SNpe) neurons. (C) 2004 Elsevier B.V All rights reserved.
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