Journal
NEURON
Volume 45, Issue 6, Pages 903-915Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2005.02.026
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Funding
- NINDS NIH HHS [NS43061, R01 NS036715, NS36715] Funding Source: Medline
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A recently described form of synaptic plasticity results in dynamic changes in the calcium permeability of synaptic AMPA receptors. Since the AMPA receptor GluR2 subunit confers calcium permeability, this plasticity is thought to occur through the dynamic exchange of synaptic GluR2-lacking and GluR2-containing receptors. To investigate the molecular mechanisms underlying this calcium-permeable (A) under bar MPA (r) under bar eceptor (p) under bar lasticity (CARP), we examined whether AMPA receptor exchange was mediated by subunit-specific protein-protein interactions. We found that two GluR2-interacting proteins, the PDZ domain-containing Protein interacting with (C) under bar (k) under bar inase (PICK1) and (N) under bar -ethy1maleimide (s) under bar ensitive (f) under bar usion protein (NSF), are specifically required for CARP. Furthermore, PICK1, but not NSF, regulates the formation of extrasynaptic plasma membrane pools of GluR2-containing receptors that may be laterally mobilized into synapses during CARP. These results demonstrate that PICK1 and NSF dynamically regulate the synaptic delivery of GluR2-containing receptors during CARP and thus regulate the calcium permeability of AMPA receptors at excitatory synapses.
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