Journal
CELL
Volume 120, Issue 6, Pages 831-842Publisher
CELL PRESS
DOI: 10.1016/j.cell.2005.01.012
Keywords
-
Categories
Funding
- NHLBI NIH HHS [HL-077588, R01 HL077588, R01 HL077588-01] Funding Source: Medline
- NIGMS NIH HHS [GM007445] Funding Source: Medline
Ask authors/readers for more resources
Cholesterol and fatty acid synthesis in mammals are controlled by SREBPs, a family of membrane bound transcription factors. Our studies identified homologs of SREBP, its binding partner SCAP, and the ER retention protein Insig in Schizosaccharomyces pombe, named sre1(+), scp1(+), and ins1(+). Like SREBP, Sre1 is cleaved and activated in response to sterol depletion in a Scp1-dependent manner. Microarray analysis revealed that Sre1 activates sterol biosynthetic enzymes as in mammals, and, surprisingly, Sre1 also stimulates transcription of genes required for adaptation to hypoxia. Furthermore, Sre1 rapidly activates these target genes in response to low oxygen and is itself required for anaerobic growth. Based on these findings, we propose and test a model in which Sre1 and Scp1 monitor oxygen-dependent sterol synthesis as an indirect measure of oxygen supply and mediate a hypoxic response in fission yeast.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available