Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 360, Issue 1455, Pages 483-496Publisher
ROYAL SOC
DOI: 10.1098/rstb.2004.1604
Keywords
sister chromatid cohesion; cohesin; SMC and Kleisin proteins; chromosome segregation; mitosis; meiosis
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The sister chromatid cohesion essential for the bi-orientation of chromosomes on mitotic spindles depends on a multi-subunit complex called cohesin. This paper reviews the evidence that cohesin is directly responsible for holding sister DNAs together and considers how it might perform this function in the light of recent data on its structure.
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