Journal
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
Volume 23, Issue 2-3, Pages 153-170Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ijdevneu.2005.01.003
Keywords
autism; brain development; frontal cortex; pyramidal neurons; head circumference
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Funding
- NIMH NIH HHS [K01-MH01814, 2-R01-MH36840] Funding Source: Medline
- NINDS NIH HHS [2-R01-NS19855] Funding Source: Medline
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While abnormalities in head circumference in autism have been observed for decades, it is only recently that scientists have begun to focus in on the developmental origins of such a phenomenon. In this article we review past and present literature on abnormalities in head circumference, as well as recent developmental MRI studies of brain growth in this disorder. We hypothesize that brain growth abnormalities are greatest in frontal lobes, particularly affecting large neurons such as pyramidal cells, and speculate how this abnormality might affect neurofunctional circuitry in autism. The relationship to clinical characteristics and other disorders of macrencephaly are discussed. (C) 2005 ISDN. Published by Elsevier Ltd. All rights reserved.
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