Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 12, Issue 4, Pages 378-379Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb908
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Funding
- NIAMS NIH HHS [AR35186] Funding Source: Medline
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Molecular motors play a central role in cytoskeletal-mediated cellular processes and thus present an excellent target for cellular control by pharmacological agents. Yet very few such compounds have been found. We report here the structure of blebbistatin, which inhibits specific myosin isoforms, bound to the motor domain of Dictyostelium discoideum myosin II. This reveals the structural basis for its specificity and provides insight into the development of new agents.
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