Journal
JACC-CARDIOVASCULAR INTERVENTIONS
Volume 8, Issue 15, Pages 1966-1974Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jcin.2015.08.031
Keywords
ischemia duration; myocardial infarction; PCI; perfusion; STEMI
Categories
Funding
- Medicines Company
- Bristol-Myers Squibb/Sanofi
- Eli Lilly
- Company/Daiichi-Sankyo
- Regado Biosciences
- AstraZeneca
- STENTYS
- Abbott Vascular
- Boston Scientific
- St. Jude Medical
- Abbott
- Adamed
- Adyton Medical Polska
- Abiomed Europe
- Biotronik
- Balton
- Bayer
- B. Braun
- BioMatrix
- Boehringer Ingelheim
- Bracco
- Bristol-Myers Squibb
- Comesa Polska
- Cordis
- Cook
- Covidien Polska Sp. z o. o.
- DRG MedTek
- EuroCor
- Hammermed
- GE Healthcare
- Glaxo
- InspireMD
- Iroko Cardio International
- Medianet Sp. z o.o.
- Medtronic
- Meril Life Sciences
- Merck Sharp Dohme
- Orbus-Neich
- Pfizer
- Possis
- ProCardia Medical
- Promed
- REVA Medical
- Sanofi-Aventis
- Siemens
- Solvay
- Terumo
- Tyco
- Volcano
- Elixir Medical
- Atrium Medical
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OBJECTIVES This study sought to investigate the effect of treatment delay on microvascular reperfusion in ST-segment elevation myocardial infarction (STEMI) patients from the large, multicenter, prospective HORIZONS-AMI (Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction) trial. BACKGROUND Despite restoration of epicardial blood flow during primary percutaneous coronary intervention (PCI), one-third of patients do not obtain myocardial perfusion due to impairment in the microvascular circulation. METHODS We examined the effect of symptom onset-to-balloon time (SBT) and door-to-balloon time (DBT) on myocardial reperfusion during primary PCI in STEMI, utilizing resolution of ST-segment elevation (STR) and the myocardial blush grade (MBG). The primary analysis was the relationships between SBT <= 2, >2 to 4, and >4h and DBT <= 1, >1 to 1.5, >1.5 to 2, and >2 h with MBG and STR. Clinical risk was assessed using a modified version of the Thrombolysis In Myocardial Infarction risk score for STEMI. RESULTS In 2,056 patients, absent microvascular perfusion (MBG 0/1) and STR (STR <30%) after primary PCI was significantly more common in patients with longer SBT, in patients with both low and high clinical risk profiles. By multivariable analysis, SBT (p < 0.0001), anterior infarction (p < 0.0001), reference vessel diameter (p - 0.005), lesion minimum lumen diameter (p < 0.0001), hyperlipidemia (p = 0.03), and current smoking (p = 0.001) were independent predictors of MBG 0/1, whereas SBT (p = 0.007), anterior infarction (p < 0.0001), and history of renal insufficiency (p = 0.0002) were independent predictors of absent STR. DBT (p < 0.0001) was an independent predictor of MBG 0/1. MBG 0/1 and STR <30% identified patients with increased 3-year mortality. CONCLUSIONS The present study suggests that delay in mechanical reperfusion therapy during STEMI is associated with greater injury to the microcirculation. (C) 2015 by the American College of Cardiology Foundation.
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