Journal
TRENDS IN BIOTECHNOLOGY
Volume 23, Issue 4, Pages 186-192Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2005.02.005
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Funding
- NIGMS NIH HHS [GM 62958-01] Funding Source: Medline
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The promising recognition characteristics exhibited by biomolecules have caused significant interest in biomolecule-based sensor strategies. Here we review several emerging biosensor designs that use modulated electron or energy transfer to a bio-specific ligand as the signaling mechanism. The efficiencies of both electron transfer and energy transfer are strongly dependent on donor-acceptor distance. When coupled with the large conformational changes sometimes associated with biomolecular recognition, these distance-dependant processes provide a robust means for generating optical and electronic signals.
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