Journal
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
Volume 140, Issue 2, Pages 153-160Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molbiopara.2004.12.010
Keywords
Plasmodium falciparum; gametocytogenesis; chromosome 9; transfection
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Gametocytogenesis is fundamental for transmission of the malaria parasite Plasmodium falciparum from the human host to the mosquito vector, yet very little is understood about what triggers the switch between asexual reproduction and gametocytogenesis. Arresting the progression through the sexual cycle would block transmission of this disease. Here we identify a novel gene in P. falciparum that when genetically silenced reduces gametocyte production by a factor of 6, and when complemented up-regulates gametocyte-specific gene transcription. (c) 2005 Elsevier B.V. All rights reserved.
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