Journal
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
Volume 35, Issue 2, Pages 159-166Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10803-004-1993-7
Keywords
Asperger syndrome; familial; prenatal; perinatal
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Objective: Study familial and pre- and perinatal factors in Asperger Syndrome (AS). Methods: One hundred boys with AS had their records reviewed. Pathogenetic subgroups were defined according to presence of medical syndromes/chromosomal abnormalities, indices of familiality, and pre- and perinatal risk factors predisposing to brain damage. Results: No major index of pathogenetic factors was found in 13%, a syndrome/chromosomal abnormality in 8%, pre- or perinatal risk 13%, combined pre- or perinatal risk and family history in 11%, and family history only in 55% Comment: About 50% of all boys with AS have a paternal family history of autism spectrum disorder. Pre- and perinatal risks appear to be important in about 25% of cases.
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