Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 94, Issue 5, Pages 890-898Publisher
WILEY
DOI: 10.1002/jcb.20352
Keywords
enhancer; transcription; enhanceosome; Cis-regulatory element
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Funding
- PHS HHS [NIH 56976] Funding Source: Medline
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in higher eukaryotes, transcriptional enhancers play critical roles in the integration of cellular signaling information, but apart from a few well-studied model enhancers, we lack a general picture of transcriptional information processing by most enhancers. Here we discuss recent studies that have provided fresh insights on information processing that occurs on enhancers, and propose that in addition to the highly cooperative and coordinate action of enhanceosomes, a less integrative, but more flexible form of information processing is mediated by information display or billboard enhancers. Application of these models has important ramifications not only for the biochemical analysis of transcription, but also for the wider fields of bioinformatics and evolutionary biology. (c) 2005 Wiley-Liss, Inc.
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