Journal
CHEMBIOCHEM
Volume 6, Issue 4, Pages 659-667Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.200400366
Keywords
antimalarial; artemisinin; glycosylamine; phase-transfer catalysis; synthesis
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An economical phase-transfer method is used to prepare 10-arylaminoartemisinins from DHA and arylamines, and artemether, arteether, and artelinate from the corresponding alcohols. In vivo sc screens against Plasmodium berghei and R yoelii in mice reveal that the p-fluorophenylamino derivative 5g is some 13 and 70 times, respectively, more active than artesunate; this reflects the very high sc activity of 10-alkylaminoartemisinins. However, through the po route, the compounds are less active than the alkylaminoartemisinins, but still approximately equipotent with artesunate.
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