Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 17, Issue 2, Pages 107-111Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2005.01.001
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Spatial and temporal separation of signal transduction pathways often determines the specificity in cellular responses. Recent advances have improved our understanding of how growth factor signalling is influenced by the formation of molecular complexes (signalosomes) in distinct cellular compartments. There has also been new insight into the mechanisms that determine the signalling competence of these complexes and their role in receptor endocytosis, retrograde trafficking in neurons and restricted protein biosynthesis, and many examples have been found where signalosome deregulation leads to disease.
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