Journal
MOLECULAR PSYCHIATRY
Volume 10, Issue 4, Pages 336-344Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.mp.4001622
Keywords
gene; addiction; comorbidity; novelty/sensation seeking
Funding
- NIDA NIH HHS [R01 DA 13232] Funding Source: Medline
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Despite what is often believed, the majority of those who experiment with substances with a dependence potential do not develop dependence. However, there is a subpopulation of users that easily becomes dependent on substances, and these individuals exhibit pre-existing comorbid traits, including novelty seeking and antisocial behavior. There appears to be a genetic basis for the susceptibility to dependence and these comorbid traits. Animal studies have identified specific genes that can alter susceptibility to dependence and response to novelty. The mechanisms underlying the genetic susceptibility to dependence and response to novelty are complex, but genetic susceptibility plays a significant role in the transition from substance use to dependence and from chronic use to addiction. We discuss two models to explain how genetic variations alter dependence susceptibility. Identification of the specific genes involved in these processes would help to identify individuals that are vulnerable to dependence/addiction and to devise novel treatment strategies.
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