Journal
JOURNAL OF NATURAL PRODUCTS
Volume 68, Issue 4, Pages 572-573Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np049650x
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A new pyrrolizidine alkaloid, cremastrine (1), was isolated from the bulbs of Cremastra appendiculata. Its configuration was determined by spectroscopic and chemical analyses. Compound 1 inhibited the binding of tritium-labeled N-methylscopolamine to the muscarinic M3 receptor with a K-i value of 126 nM.
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