Journal
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Volume 59, Issue 3, Pages 557-564Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejpb.2004.10.001
Keywords
intranasal administration; in situ gel; fluorescein dextran; deacetylated gellan gum; nasal mucosa; olfactory mucosa; fluorescence microscopy
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The nasal uptake of a 3000 Da fluorescein dextran (FD3) was investigated in rats, using fluorescence microscopy. The uptake from a formulation containing deacetylated gellan gum, an in situ gelling agent, was compared to that from a mannitol solution. Additionally, the rheological behavior of the gellan gum in water and saline was studied. It was shown that the gellan gum solution was easily administered owing to its low viscosity, and upon contact with the mucosa, a gel was formed. The epithelial uptake and transfer of FD3 appeared to be increased and prolonged using the gellan gum formulation. This increase was not accompanied by qualitative changes of the epithelial FD3 distribution or any visible harmful effects. (c) 2004 Elsevier B.V. All rights reserved.
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