Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 13, Issue 7, Pages 2397-2411Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2005.01.044
Keywords
pyrazolo[1,5-alpha]pyridine; antiherpetic; HSV
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A novel series of potent pyrazolo[1,5-a]pyridine inhibitors of herpes simplex virus 1 replication have been identified. Several complimentary synthetic methods were developed to allow facile access to a diverse set of analogs from common late stage intermediates. Detailed examination of the amine substituents at the C2' position of the pyrimidine and C7 position of the core pyrazolopyridine is described. The antiviral data suggests that non-polar amines are preferred for optimal activity. Additionally, the 2' position has been shown to require an NH group to retain activity levels similar to that of the gold standard acyclovir. (c) 2005 Elsevier Ltd. All rights reserved.
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