Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 161, Issue 1-2, Pages 21-28Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2004.12.006
Keywords
nociceptin/orphanin FQ; adhesion molecule; dextran sulfate sodium; colitis
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Nociceptin/orphanin (Noc/oFQ), endogenous agonist for nociceptin receptor (NOR), is thought to be a stimulator of neurogenic inflammation. We investigated the possible role of Noc/oFQ in the development of colitis using NOR-deficient mice treated with dextran sulfate sodium (DSS). Colitis was significantly improved in NOR-deficient mice against wild-type mice. Expression level of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and infiltrating cells also significantly decreased in NOR-deficient mice against wild-type mice. Nociceptin expression increased in wild-type mice after DSS treatment. These results suggest stimulation by Noc/oFQ deteriorates colonic inflammation via up-regulation of adhesion molecule. (C) 2004 Elsevier B.V All rights reserved.
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