Journal
CELL CYCLE
Volume 4, Issue 4, Pages 578-581Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.4.4.1593
Keywords
p110 alpha; PIK3CA; Akt; oncogene; transformation; gain-of-function mutation
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The PI3K signaling pathway is upregulated in numerous cancers. The catalytic subunit p110 alpha of PI3K shows hot spot mutations in nearly 30% of several types of solid tumors. The most prominent of these mutations result in gain of enzymatic function, activate Akt signaling and induce oncogenic cellular transformation. The mutated p110 alpha proteins are ideal targets for specific small molecule inhibitors that discriminate between the oncogenic and the wild-type forms of the enzyme. Such inhibitors could become highly effective anti-cancer drugs.
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