Journal
NEUROLOGICAL RESEARCH
Volume 27, Issue 3, Pages 287-301Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1179/016164105X25234
Keywords
traditional eastern medicine; traditional Chinese medicine; herb; neuroprotection; brain ischemia; stroke
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Traditional Eastern Medicine (TEM) has a long history in stroke therapy and its therapeutic efficacy has been confirmed by clinical studies. Extensive experience and abundant clinical data on TEM in stroke treatment have been accumulated over the past thousand years. Basic and clinical research in TEM constitutes a potentially rich source for new drug discovery and development with the integration of TEM and Western pharmacology. In recent years, man attempts have been made to document research data from extracts of composite formulas, sing herbs, or single compounds from TEM herbs, according to orthodox pharmacological actions. This article reviews herbs and prescriptions that have been documented to have a neuroprotective effect in in vitro and in vivo ischemic model systems, and the neuroprotective compounds isolated from them. I also discuss the neuroprotective mechanisms of prescriptions, herbs, and single compounds relevant to the treatment of brain ischemia, including anti-oxidant, anti-excitotoxic, and anti-inflammatory effects.
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