Journal
TRENDS IN IMMUNOLOGY
Volume 26, Issue 4, Pages 177-179Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2005.02.004
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It has recently been shown that small interfering RNA (siRNA)-mediated inhibition of suppressors of cytokine signalling 1 (SOCS1) function enhances the immunostimulatory capacity of dendritic cells (DCs), which leads to more effective cancer vaccination. This recent study demonstrates the importance of negative regulation of DC maturation and functions for DC-based immunotherapy.
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