4.4 Article

Role of the rep helicase gene in homologous recombination in Neisseria gonorrhoeae

Journal

JOURNAL OF BACTERIOLOGY
Volume 187, Issue 8, Pages 2903-2907

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.187.8.2903-2907.2005

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Funding

  1. NIAID NIH HHS [R01 AI044239, R37 AI033493, R01 AI033493] Funding Source: Medline
  2. NIGMS NIH HHS [T32 GM008061] Funding Source: Medline

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In Escherichia coli, the Rep helicase has been implicated in replication fork progression, replication restart, homologous recombination, and DNA repair. We show that a Neisseria gonorrhoeae rep mutant is deficient in the homologous-recombination-mediated processes of DNA transformation and pilus-based colony variation but not in DNA repair.

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