Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Volume 73A, Issue 1, Pages 48-54Publisher
WILEY
DOI: 10.1002/jbm.a.30244
Keywords
hydroxyapatite sol-gel coating; microarc oxidation (MAO); titanium; in vitro cell responses
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A thin hydroxyapatite (HA) layer was coated on a microarc oxidized titanium (MAO-Ti) substrate by means of the sol-gel method. The microarc oxidation (anodizing) enhanced the biocompatibility of the Ti, and the bioactivity was improved further by the sol-gel HA coating on the anodized Ti. The HA sol was aged fully to obtain a stable and phase-pure HA, and the sol concentration was varied to alter the coating thickness. Through the sol-gel HA coating, the Ca and P concentrations in the coating layer increased significantly. However, the porous morphology and roughness of the MAO-Ti was altered very little by the sol-gel treatment. The proliferation and alkaline phosphatase (ALP) activity of the osteoblast-like cells on the MAO/HA sol-gel-treated Ti were significantly higher than those on the MAO-Ti without the HA sol-gel treatment. (c) 2005 Wiley Periodicals, Inc.
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