4.7 Article

Trifluoroacetic acid-mediated hydroarylation: Synthesis of dihydrocoumarins and dihydroquinolones

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 70, Issue 7, Pages 2881-2883

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo0477650

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Funding

  1. NIGMS NIH HHS [P50 GM069663] Funding Source: Medline

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Trifluoroacetic acid mediates the hydroarylation of alkenes to afford dihydrocoumarins and dihydroquinolones in good yield. Intermolecular hydroarylation of cinnamic acids by phenols is particularly facile, which leads to the conclusion that previous reports of palladium-catalyzed hydroarylation of cinnamic acids in trifluoroacetic acid are erroneous.

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