Journal
LEUKEMIA RESEARCH
Volume 29, Issue 4, Pages 401-405Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2004.09.010
Keywords
dimethylsulfoxide; PTEN; leukemic cell differentiation; NF-kappa B
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Dimethylsulfoxide (DMSO) has been known to differentiate HL60 cells into neutrophil like cells. Here, we provide an evidence for the involvement of tumor suppressor PTEN, an antagonist of phosphatidylinositol 3-kinase (PI3K) in the DMSO-induced differentiation of HL60 cells. DMSO upregulated PTEN with unaffecting the expression of PI3K. The upregulation of PTEN by DMSO lead to the decrease of Akt phosphorylation, a downstream of PI3K. The DMSO-induced upregulation of PTEN might be mediated by NF-KB activation, which was evidenced by the blockage of DMSO-induced PTEN upregulation with an NF-kappa B inhibitor, pyrrolidine dithiocarbamate (PDTC). (c) 2004 Elsevier Ltd. All rights reserved.
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